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New methods of treating hepatitis C

Cdc-hepatitis-c Hepatitis C is a viral disease that is considered quite common and poses a certain threat to society.It's no wonder that scientists and doctors are looking for methods of therapy that will be intense, effective, but not aggressive.What has been achieved in this direction and what is already known to specialists about the treatment of hepatitis C?

Contents:

What is known about the treatment of hepatitis C

Hepatitis with Antiviral drugs for treating the disease in question have been used for more than 20 years.The goal of this therapy is to remove the virus from the body at the stage of the disease, which precedes the development of cirrhosis or liver cancer.Eliminating the patient from the virus, it is possible to achieve an end to the inflammatory process in the liver, to prevent the rapid progression of pathology.Back in the early 1990s, hepatitis C was considered an incurable disease - for example, even if antiviral therapy was used at an early stage of the disease, its effectiveness was only 6-7%.To date, the effectiveness of antiviral treatment is 60-70% - the effectiveness of treatment has increased by 10%, and this is simply a luxurious result for such a short period of time.

What can be the results of treatment

The results of treatment are unlikely to predict the doctor - it depends on many factors.

First, the variety( genotype) of the hepatitis C virus is of great importance. Genotype 1b is most often diagnosed, less often - genotypes 1a, 2a, 3a.It is believed that the highest effectiveness of treatment in patients with genotypes 2a and 3a - it reaches 95%.The results of treatment are influenced by the activity of the virus, so that before the appointment of therapy to the patient, the genotype of the virus and the quantitative analysis of the viral RNA are carried out.

Secondly, the effectiveness of therapy depends on the age of the patient, the stage and duration of the disease - for example, the treatment of hepatitis C with already available cirrhosis is quite low in effectiveness.In addition, the indicator in question depends on the degree of obesity of the patient, on the number of alcohol consumed by the patient and other factors.

Thirdly, an important factor is the patient's readiness for long-term treatment and the doctor's experience.The patient should strictly comply with the prescription of the doctor, strictly adhere to the recommended dosages of medications, do not violate the rules of rational nutrition, regularly visit the attending physician to monitor the pathology and, if necessary, correction of therapy.A doctor should have an impressive experience working with patients with hepatitis C, know and apply the latest achievements of world practice.Only many years of experience will allow a doctor to individually select the treatment of hepatitis C and achieve the maximum result even in difficult cases, to minimize side effects.

Do you need to treat hepatitis C?

Most often, hepatitis C is diagnosed accidentally when a person feels and feels completely healthy.And in such cases, patients simply do not understand why they need to undergo long-term treatment - nothing bothers you after all!Patients should know that hepatitis C refers to slowly progressing diseases: for example, cirrhosis of the liver is formed only 20-30 years after infection, but if the patient is actively taking drugs / alcohol, complex / aggressive medicines, the development of this severe disease occurs much faster.The insidiousness of hepatitis C lies in the fact that it is asymptomatic in the first years, and the primary signs of health disorders start to worry only when there is already a cirrhosis of the liver.And this disease can lead to jaundice, the accumulation of fluid in the abdomen, bleeding and impaired consciousness.In addition, the hepatitis C virus can affect not only the liver, but also the kidneys, joints, skin.

New methods of treating hepatitis C

The classical treatment regimen for the disease in question implies combined antiviral therapy.And it gives quite good results!But science "does not stand still", so modern medicine can offer patients the newest methods of treating hepatitis C.

Sofosbuvir and Daklatasfavir

Sofosbuvir These are new drugs for the treatment of the disease in question that have successfully passed clinical trials in the US.The efficacy of therapy with with Sofosbuvir and with Daklatasfavir was proven even in cases where triple therapy was impotent.

These drugs are equally effective in treating all three genotypes( varieties) of the hepatitis C virus and they do not cause such powerful side effects as are typical for classical therapy, although the patient may have nausea, fatigue and periodic low-intensity headaches.

The World Health Organization has already approved the drug Sofosbuvir, the second drug is currently at the stage of clinical research.According to the leaders of these tests, approval for the use of Doklatasfavir will soon be obtained and then new possibilities will be opened in the treatment of hepatitis C.

Extracorporeal hemocorrection

This procedure is a kind of plasmapheresis - purification of blood through a special filtering device that helps to remove pathogens.Hemocorrection does not just purify blood, but reduces the level of viral load hundreds of times, and this allows doubling the effectiveness of classical antiviral therapy.

Extracorporeal hemocorrection is aimed, first of all, at eliminating or reducing the severity of side effects. It is indicated to patients:

  • Hepatitis with with enlarged liver and spleen;
  • with symptoms of hepatitis, when not only the liver is affected by the virus;
  • with a rapidly progressive inflammatory process in the liver;
  • with little( or complete absence) of the effectiveness of classical antiviral therapy;
  • with long-term elevated body temperature.

Extracorporeal hemocorrection is not an independent type of treatment, but is an activity included in complex therapy.Doctors often use this type of treatment, thereby increasing the effectiveness of antiviral therapy and reducing the toxic effect on the body of medicines.

Treatment of patients with 1 hepatitis C genotype

This refers to the treatment of such patients with and aspartic and ASE35ASD preparations, which increased the effectiveness of therapy to 70-80%. Patients need to know some specific features of therapy with Telaprevir and Bocepreviros:

  1. Hepatitis with These drugs can only be used to treat patients with the first genotype of the hepatitis C virus.
  2. These drugs can not be administered alone, they are necessarily included in complex therapy with Ribavirin and Peginterferon -It will be triple therapy.
  3. Drugs taken internally: Boceprevir - from the second month of therapy, Telaprevir - from the 12th week of treatment.
  4. These drugs are effective in 60% of cases in the treatment of compensated liver cirrhosis.
  5. No triple therapy is possible if the patient has contraindications to taking at least one of the above medicines.
  6. Side effects with triple therapy may be more intense.

Antiviral therapy is the only method for treating hepatitis C. Even the use of modern medicines is the same antiviral therapy, but with new medicines.It is necessary to realize that the diagnosis of "hepatitis C" is not a sentence, an experienced doctor will necessarily select individual therapy and will achieve victory over the disease.

Tsygankova Yana Aleksandrovna, medical reviewer, therapeutist of the highest qualification category


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