Ofloxacin: instructions for use, analogues
Jul 03, 2018
Ofloxacin, a medicinal product that belongs to the group of antimicrobial and antiparasitic agents, is included in the category of derivatives of naphthydrins, quinolones and fluoroquinolones.If to speak not strict medical language, it is possible to designate the considered medicinal preparation, as a broad-spectrum antibiotic, whose main active substance is actually ofloxacin.Table of contents: Principle of action of Ofloxacin Occurrence of use of Ofloxacin Contraindications according to the instruction Rules of application Ofloxacin, dosages Adverse events Analogues of Ofloxacin
Principle of action Ofloxacin
Very effective drug presented against Gram-negative pathogens,And in those cases, if other drugs of the same group did not give a therapeutic effect.
Taking Ofloxacin inside and still very effective, very quickly absorbed in the organs of the gastrointestinal tract and almost in full concentration enters the tissues, organs, bile, sputum, skin, human saliva.The maximum concentration of the main active agent in the blood( in the plasma) is observed already an hour after ingestion.Offloxacin is released unchanged, more than half of the dose is excreted after 6 hours, but the presence of the main active substance in the urine can be detected even after the day( it can be a single dose).
Reason for using Ofloxacin
Since the drug in question has a broad spectrum of antibacterial action, it is used in almost all fields of medicine. Here are just some unconditional reasons for prescribing of Ofloxacin to patients:
- pathological processes of infectious origin in the upper respiratory tract;
- any infectious processes in soft tissues and on skin integuments;
- furunculosis and carbuncles;
- diseases of the infectious etiology of the urinary tract;
- pathology of the abdominal cavity, kidney;
- diseases of female genital organs( gynecological inflammations and infections).
In addition, Ofloksatsin has a harmful effect on mycobacteria that cause tuberculosis, so it is often included in the complex therapy of this disease.
Contraindications according to
The categorical contraindications to the administration and use of Ofloxacin are:
- child's age;
- adolescence up to 15 years;
- individual intolerance to quinolones;
- lactation period.
With special care, this medication is prescribed for patients with impaired renal function - they select an individual regimen( usually at the beginning of treatment, Ofloxacin is taken in usual doses, and then they decrease) and maintain a constant control over the patient's well-being.
Rules for the use of Ofloxacin, dosage
This medication is prescribed for the treatment of various infectious diseases only for adult patients. Of course, the attending physician will choose the dosage and duration of therapy individually, but there are also general rules for the appointment:
- wounds, carbuncles, boils, phlegmon, infections of the abdominal cavity and upper urinary tract - take 1 tablet twice a dayday;
- infectious diseases of the joints and bones - Ofloxacin is administered 2 tablets twice a day;
- inflammatory process in the urethra( urethritis) and the prostate gland( prostatitis) - an effective dose will be 2 tablets twice a day.
Note: if the infectious disease is severe, the doctor may increase the daily dosage of the drug in question.
The course of treatment is set individually, but experts recommend adhering to the general principles of using all antibacterial drugs - they need to be taken until the symptoms disappear completely and 3 days after.Typically, the therapeutic course is a maximum of 10 days, if the infection is easy, then the duration of taking Ofloxacin can be reduced to 4-5 days, but the decision can only be made by the attending physician.It is strictly forbidden to take the drug in question for more than a month.
Statistically, Ofloxacin is well tolerated by patients, but there are cases when there are side effects when using this antibiotic in a patient:
- swelling of the vocal cords and eyes;
- a violation of appetite, namely - its complete absence;
- reduction of granulocytes and leukocytes in the blood;
- problems with psycho-emotional background - bad mood, unexplained irritation;
- spontaneous rashes on the skin, itching.
Some patients may increase the sensitivity of the skin to sunlight and therefore patients who are on treatment with Ofloxacin are not recommended to spend a long time under direct sunlight.
Analogs of Ofloxacin
The pharmacological industry also produces analogs of the drug in question that have the same effect with Ofloxacin.
The drug is used to treat infectious diseases caused by not one, but several pathogens. The official indications are the following indications for the use of Cyfran:
- osteomyelitis occurring in acute and / or chronic forms;
- Diarrhea of bacterial etiology;
- lung abscess;
- is an arthritis of the septic type.
The considered analog of Ofloxacin is administered only in an individual dosage - the doctor takes into account not only the specific disease, but also the general condition of the patient, severity of the pathology, history of chronic diseases, age and weight of the patient .Very carefully prescribes the presented drug to patients with disorders of the central nervous system( epilepsy, atherosclerosis) in the anamnesis.
The figure can be taken regardless of the food intake, but doctors recommend that patients take this medication on an empty stomach, that is, before meals - so its bioavailability increases.
As a rule, Tsifran is not used in pediatric practice, but if the physician deems it necessary, then the daily dosage of the drug for the child should be a maximum of 10 mg of the drug per 1 kg of the patient's weight.
Tsifran, unlike Ofloksatsina, is produced not only in tablet form, but also as a solution for injections.
This drug effectively acts not only on gram-negative bacteria, but also on gram-positive bacteria. Moreover, the main active substance of Ciprolet damages pathogens both in a state of rest and in a state of active reproduction.
TSiprolet is used for a variety of infectious / inflammatory pathologies of ENT organs, the genitourinary system, abdominal organs, joints and bones, the organs of the gastrointestinal tract, skin and soft tissues.The considered analog of Ofloxacin is also available in the form of eye drops, it is used to prevent the development of suppurative processes in the postoperative period with surgical interventions on the eyes, as a treatment for pathologies that have arisen after trauma, and for the treatment of any inflammatory diseases.
Even prolonged use of TSiprolet is usually well tolerated by patients, but there may be various side effects of - nausea and vomiting, insomnia, abdominal pain, anorexia, vision and hearing problems, allergic reactions.If there are any changes in the health status, you should seek qualified medical help.Yes, side effects do not lead to irreversible consequences, but it will still be necessary to stop taking an antibacterial drug of a wide spectrum of action in time.
TSiprolet is not assigned to pregnant women and children under the age of 15 years.
The action of this analogue practically does not differ from the action of Ofloxacin - it effectively affects various pathogens, can be used in most infectious pathological processes, regardless of their location.
Levofloxacin is available in the form of tablets and solutions for intravenous administration. It is compulsory to prescribe the considered analog of Ofloxacin, it is necessary to ensure control over the state of health.The fact is that with the intake of glucocorticosteroid agents there may be a rupture of the tendon, if the patient uses anticoagulants, then changes in the blood formula are possible.On the background of the use of Levofloxacin, blood coagulability can be disrupted, so the patient is periodically required to do a control laboratory examination of the blood.
The considered analog of Ofloxacin, if the dosage is incorrectly chosen, can trigger the appearance of overdose symptoms:
- severe dizziness;
- nausea and vomiting( multiple);
- convulsive syndrome of a non-intensive nature;
- formation of erosion on mucous membranes.
There is no specific antidote in the treatment of overdose with levofloxacin, therefore, doctors perform symptomatic therapy.As a rule, even a serious condition with an overdose does not lead to irreversible consequences.
Ofloxacin is an antibacterial drug that is often a priority in the choice of treatment.It is really effective against most pathogens, belongs to the group of antibiotics of the latest generation.
Tsygankova Yana Aleksandrovna, medical reviewer, therapeutist of the highest qualification category