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Ascofen: instructions for use, analogues


Ascofen is a combined medicine with analgesic, antipyretic and mild psychostimulating effect.It is intended for symptomatic therapy and does not affect the cause of the pathology and the overall duration of the disease.

Table of contents: Components and dosage form When are Ascophenes appointed?Who should not take Ascofen?Dosages Pharmacological action Interaction with other drugs Side effects Ascofen during pregnancy Special instructions Storage and dispensing conditions from pharmacies Analogues of Ascophene

Components and dosage form

The drug is available in the form of tablets for oral administration.In 1 tablet of Ascophene, 0.2 g of acetylsalicylic acid, 0.2 g of phenacetin and 0.04 g of caffeine are present.In the preparation Ascofen P instead of phenacetin contains a safer component - paracetamol( 0.2 g).Tablets are supplied in cell packs( 10 pieces each).

In what cases is Ascofen appointed?

This pharmacological agent is recommended for symptomatic therapy of colds and acute respiratory viral infections( including influenza) - relief of pain syndrome( feelings of "aches" in the body) and lowering of temperature.

Other indications include:

  • Ascofen-indications-for-use migraines;
  • neuralgia( including thoracic radicular syndrome);
  • myalgia;
  • arthralgia;
  • toothache in the background of pulpitis and periodontitis;
  • soreness in menstruation( algodismenorea);
  • febrile syndrome( including with rheumatic pathologies).

Who should not take Ascofen?

The drug can not be used in patients with individual hypersensitivity to one or more of its components in order to avoid the development of allergic reactions.

Diseases and pathological conditions that are contraindications:

  • erosion and gastrointestinal ulcers( in the acute stage);
  • Gastrointestinal bleeding;
  • exfoliating aortic aneurysm;
  • atherosclerotic lesions of coronary vessels;
  • marked functional liver failure;
  • severe renal dysfunction;
  • portal hypertension;
  • poor blood clotting;
  • diseases of the hematopoietic system;
  • "aspirin triad"( bronchial asthma + polyposis of the nose + intolerance to salicylates or other NSAIDs).

Please note: is not assigned to children and teenagers under 15 years of age!


Askofen Single dose for the management of moderate pain syndrome - 1 tablet;With severe pain you can take 2 pieces at once.Multiplicity of reception - no more than 3 times a day. The drug is highly recommended after a meal, with plenty of fluids.Wash tablets preferably with milk or alkaline mineral water to reduce irritation of the mucous membranes of the digestive tract.

Important: should not take Ascoffen for longer than 1 week in a row( to reduce the temperature - more than 3 days).If necessary, continue treatment, consult with your doctor.Long-term therapy requires monitoring of the pattern of peripheral blood and liver function.

Pharmacological action of

Acetylsalicylic acid depresses the process of biosynthesis of mediators of pain and inflammation - prostaglandins, due to which the puffiness and severity of pain syndrome decreases in inflammatory genesis. This substance is able to slow platelet aggregation, which reduces the risk of thrombosis, but increases the likelihood of bleeding.Analgesic and antipyretic properties of acetylsalicylic acid enhances phenocetin.The paracetamol present in Ascofen-P indiscriminately blocks the enzyme cyclooxygenase, which reduces the production of prostaglandins.It also directly affects the hypothalamic center of thermoregulation.Its advantage over phenocetin is that methhemoglobin is not formed in the metabolic process.Caffeine has psychostimulating and vasodilating properties.This component normalizes the tone of the cerebral vessels, accelerates the blood flow, reduces the feeling of physical and mental fatigue and excites the respiratory center.The substance enhances the effect of the remaining ingredients.

After ingestion, the active components are absorbed into the digestive tract quickly and almost in full( about 90%).The process of biotransformation takes place in the liver, and the excretion of unchanged substances and their metabolites is mainly through the kidneys( approximately 80%);Some amount is excreted with bile.

Interaction with other medicines

Ascofen potentiates the action of anticoagulants of indirect action and antiaggregants, which increases the risk of bleeding of various locations. It also enhances the effect of hypoglycemic drugs and steroids( glucocorticoids increase the likelihood of developing glaucoma).

With parallel administration, the effectiveness of antihypertensive drugs and individual diuretics decreases.Severe poisoning even with a slight excess of allowable dosages may develop if the patient receives phenytoin, tricyclic antidepressants, antibacterial Rifampicin, or an antiviral drug Zidovudine.

During treatment, it is highly undesirable to take other NSAIDs, because the risk of toxic effects on the kidneys increases.

Side effects of

Most patients are well tolerated by Ascophene.

Allergies to components do not exclude skin itching and hives, as well as angioedema.In severe cases, anaphylactic shock is possible.

In rare cases, the following side effects are noted on the background of therapy:

  • headache;
  • dizziness;
  • feeling tired;
  • is a dyspeptic disorder;
  • impaired clarity of visual perception near;
  • intestinal disorders;
  • epigastric pain( with development or exacerbation of gastritis and ulcers);
  • discomfort or pain of the abdominal region( with liver damage).

Ascofen during pregnancy

The components of the drug are absorbed into the systemic bloodstream, bypass the hemato-placental barrier and penetrate into the breast cavity. It does not have an embryotoxic or mutagenic effect, but it is better to give up this medication for the time of gestation and breastfeeding of the baby, especially in I and III trimesters .If it is necessary to carry out symptomatic therapy during lactation, please consult with your doctor.In such cases it is usually recommended to temporarily transfer the child to artificial milk formula.

Special instructions

For the duration of treatment should refrain from taking alcoholic beverages and pharmacy tinctures, because ethanol multiplies the risk of toxic damage to the liver.

It is also advisable to abandon the management of vehicles and other activities requiring increased concentration.

Storage and dispensing conditions from pharmacies

You do not need a doctor's prescription to purchase this analgesic and antipyretics.

The tablets should be kept in places with a minimum level of humidity, at a temperature not exceeding + 25 ° С.

The shelf life for Askofen is 4 years, and for Askofen P - 4 years from the date of issue( marked on the package).

Keep out of the reach of children!

Analogues of Ascophene

The analogues of Ascophene according to the active substances are:

  • Migrainol Extra;
  • Citramon;
  • Excedrine;
  • Co-plus;
  • Citramarin.

Plisov Vladimir, medical reviewer

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