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Ibuprofen and its analogues: indications, way of application, side effects

Ibuprofen Ibuprofen is a widely used drug from the group of non-steroidal anti-inflammatory drugs( NSAIDs).The medicine was synthesized in the sixties of the twentieth century and since that time it has not lost its relevance.

Table of contents: Properties of Ibuprofen Indications for use Methods of administration Adverse effects Contraindications

Properties of Ibuprofen

The active ingredient of the drug is ibuprofen, a derivative of propionic acid.The drug inhibits the activity of prostaglandins.These are substances that take part in the inflammatory process.

Ibuprofen has such effects:

  • Anti-inflammatory;
  • Analgesic;
  • Antipyretic( antipyretic).

Ibuprofen-tablets-instructions-for-use Ibuprofen should not be drunk on an empty stomach, but after a meal.This minimizes the risk of potential side effects.The drug is very well absorbed from the digestive tract and its maximum concentration in the blood reaches a half to two hours later.

Ibuprofen is available in various dosage forms: in the form of tablets, suspensions, rectal suppositories, gels, ointments.Such a variety of dosage forms is very convenient.For the treatment of myositis, arthritis, tendovaginitis, sprain, Ibuprofen ointment is used.Rectal suppositories and suspension are used to reduce body temperature in young children.

The analogues of ibuprofen are such medications as:

  • Nurofen;
  • Brufen;
  • Ibuprom;
  • IMET;
  • Ibufen.

Indications for use

Ibuprofen is one of the few anti-inflammatory drugs that can be used in children( as a suspension, rectal suppositories).Therefore, it is assigned to both adults and children.The spectrum of application of Ibuprofen is wide enough: it is any inflammatory diseases, as well as conditions accompanied by pain.

Indications for use:

  • Inflammatory diseases of the joints( rheumatoid and gouty arthritis, deforming osteoarthritis, as well as Bekhterev's disease);
  • Fever for infectious diseases( symptomatic treatment of ARVI);
  • Pain syndrome( headache, dental, muscular, menstrual pain, neuralgia, lumbalgia, ischialgia);
  • Postoperative pain syndrome.

Methods of application

Migraine-and-temperature The dose of ibuprofen for oral administration is determined by the physician taking into account the indications and age of the patient.As a rule, Ibuprofen is attributed to adults and children who reached the age of twelve in tablets of 200 mg three to four times a day.If necessary, the dose can be doubled: 400 mg three times a day.As soon as the expected therapeutic effect is achieved, the daily dose of the drug is reduced to 600-800 mg.

Important! The maximum daily concentration of Ibuprofen is 1200 mg.In case of exceeding this figure, it is possible to develop an overdose with .

Ibuprofen can be used by children weighing more than twenty kilograms from six years.Children aged six to twelve years are credited with Ibuprofen 200 mg three to four times a day.It is important that the interval between tablets is at least six hours.

In the treatment of children from three months of life as prescribed by the doctor Ibuprofen may be used in the form of rectal suppositories.Children aged three to nine months are prescribed one suppository( 60 mg) three times a day.Children from nine months to two years - one suppository( 60 mg) four times a day.

Ibuprofen in the form of an ointment or gel is applied to the lesion site and rubbed with hands until the drug is completely absorbed three to four times a day and so for two to three weeks.

Side effects

Ibuprofen is generally well tolerated.However, in some cases, the possibility of side effects is not excluded.When using any drug from the NSAID group, including Ibuprofen, ulcerogenic action may be possible.This is a side effect of the drug, which is expressed in the formation of defects( ulcers) on the mucosa of the organs of the gastrointestinal tract.Given this feature, ibuprofen should not be taken inside for more than five days.In addition, the use of drugs on an empty stomach also increases the vulnerability of the mucous membrane of the organs of the gastrointestinal tract.

According to the instructions for Ibuprofen, the following side effects may occur:

  1. Abdominal pain, nausea, vomiting, diarrhea or constipation, flatulence, heartburn, dry mouth, ulceration of the oral mucosa, GIT;
  2. Bronchospasm, shortness of breath;
  3. Tinnitus( tinnitus), blurred vision, blurred vision, dry eyes, eyelid swelling, reddening of the conjunctiva;
  4. Headache, dizziness, insomnia and daytime sleepiness, anxiety, hallucinations;
  5. Increased blood pressure, tachycardia;
  6. Kidney damage in the form of a nephrotic syndrome with the appearance of edema, acute renal failure;
  7. Allergic reactions of varying severity: from skin rash to anaphylactic shock;
  8. Anemia, leukopenia, thrombocytopenia;
  9. Increased perspiration.

Such an impressive list of side effects does not at all mean that these reactions occur in all people who use Ibuprofen.Side effects are extremely rare, but mention of them in the manufacturer's instructions is required.


Given the ulcerogenic effect of Ibuprofen, it is contraindicated in all possible erosive and ulcerative lesions of the digestive tract( peptic ulcer of the stomach and duodenum, NJC, Crohn's disease).Ibuprofen is also contraindicated in disorders of blood clotting, diseases of the optic nerve, leukopenia, thrombocytopenia, as well as hepatic, renal, heart failure.

Unconditional contraindication is the presence of hypersensitivity to the components of Ibuprofen.In addition, if hypersensitivity to other NSAIDs, in particular to aspirin, Ibuprofen is also not prescribed.

In pregnancy, the drug is used only with the indication of a doctor.Ibuprofen, although in low concentration, but still penetrates into breast milk.Because of this, lactating mothers are not recommended to use Ibuprofen.

Grigorova Valeria, medical reviewer

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