Koldakt: brief instruction, analogues
Jul 06, 2018
A cadaver is a powerful combination drug for colds and allergies.It is designed to arrest or reduce the severity of clinical symptoms, and does not affect the cause of the pathology.The components of this drug have vasoconstrictive( vasoconstrictive), anticongitious( anti-edematous) and antihistamine( anti-allergic) properties.Table of contents: Active ingredients and dosage forms What helps the Cagedact?Contraindications Admission scheme and recommended dosage Pharmacological action Side effects Overdose Interaction with other drugs Cognac during pregnancy In addition Storage and dispensing conditions from pharmacies Analogs
Active ingredients and dosage forms
This pharmacological agent is manufactured in the form of capsules( prolonged action), suspension, Powder for the preparation of solution and syrup for children.
In the capsules Koldact 50 mg of phenylpropanolamine hydrochloride and 8 g of chlorpheniramine maleate.
In each capsule, COLD CONTACT Plus, 200 mg of paracetamol is additionally present, and the dose of phenylephrine hydrochloride is half that( 25 mg).
In a 5 ml syrup A cadaver for children( 1 measuring spoon) - 10 mg of phenylpropanolamine hydrochloride and 2 mg of chlorpheniramine.
Capsules are supplied in blister( 10 pcs.), And syrup - in vials( 60 ml).
Please note! Due to the fact that the granular content of the Colduct Flu Plus capsules dissolves and absorbs into the digestive tract gradually, the medicine lasts for 12-24 hours.
What helps the Cagedact?
The drug helps to cure the symptoms of inflammation of the paranasal sinuses, as well as acute, chronic and allergic rhinitis.
A cadaver is prescribed for the following diseases:
The product eliminates swelling, sore throat, nasal congestion, rhinorrhea, and lacrimation.
Please note: preparation in capsules is not prescribed for children and adolescents under 12 years of age.
Absolute contraindication is individual hypersensitivity to active or auxiliary ingredients of the drug.
The illness can not be taken in case of severe ischemic heart disease and severe hypertension.
Dosage regimen and recommended dosages
Single dose - 1 capsule, and the frequency of admission - 2 times a day, observing the 12-hour time interval .It is recommended to drink the drug after eating.
For influenza and acute respiratory viral infection, symptomatic treatment continues for 1 to 3 days according to the indications.Allergic rhinitis requires the use of capsules Koldakt for 3-6, and chronic - up to 30 days.With sinusitis, the medication is taken on average from one to one and a half weeks.
Syrup Kids give every 4-6 hours of .
Single dosage( by age):
- 2-6 years - half teaspoon( 2.5 ml);
- 6-12 - 5 ml;
- 12 and more - 5-10 ml per reception.
Chlorpheniramine is able to block specific receptors of the main mediator of the allergy - histamine.The substance is characterized by moderately expressed sedative( soothing) and antimuscarinic properties.It reduces the permeability of the vascular walls, which helps reduce inflammatory exudation.
Another active substance, phenylpropanolamine, is a sympathomimetic of indirect action.By the nature of the action it is similar to ephedrine, but affects the central nervous system to a lesser extent.The compound helps to reduce congestion in the mucous membranes of the upper parts of the respiratory system.
The cadaver stimulates α-adrenergic receptors and narrows the vessels, thereby reducing hyperemia and swelling of the mucous respiratory tract and nasal sinuses.
Paracetamol inhibits the enzyme cyclooxygenase and affects the hypothalamic centers of thermoregulation and pain.This compound helps to knock down heat and to stop headache and muscle pain for colds and ARVI( including influenza).
After oral administration of capsules, the active ingredient is absorbed in the digestive tract gradually.The maximum serum concentration of chlorpheniramine is fixed after 2-6 hours.Its biotransformation takes place in the liver, and the unchanged substance and its metabolites are excreted mainly by the kidneys.The peak concentration of phenylpropanolamine in plasma is reached after 1-2 hours.The substance leaves the body mostly unchanged in the urine.
Side effects of
If the components are intolerant, there is a possibility of developing allergic reactions - skin itch and rash( urticaria), angioedema and bronchospasm.In severe cases, anaphylactic shock is not excluded.
Most patients are well tolerated by Coadact.
In rare cases, the following side effects are noted:
- increased blood pressure;
- dry mouth;
- feeling tired;
- psychomotor agitation;
- dysuria( difficult passage of urine);
- dyspeptic phenomena;
- intestinal disorders( diarrhea or constipation);
- visual impairment( paresis of accommodation);
- heart palpitations;
- feeling of compression in the thorax and cardialgia.
Cases of overdose There was no evidence of drug damage.At a significant excess of single and daily doses of Kodakt FluxPlus, poisoning with paracetamol is not excluded.
Interaction with other medicines
The cadaver is capable of potentiating the action of sedative( sedative) and hypnotic pharmacological agents.
For the period of treatment it is necessary to refrain from taking pharmacy alcoholic tinctures and alcoholic beverages.
Parallel use of furazolidone and monoamine oxidase inhibitors increases the likelihood of a sudden increase in blood pressure( up to the hypertensive crisis).With the simultaneous use of Halothane, ventricular arrhythmia is not excluded.Guanethidine increases the activity of phenylpropanolamine.
Acquired during pregnancy
It is not recommended to take this medication against cold and flu during gestation and breastfeeding.Especially it concerns Koldakt FlyuPlyus containing paracetamol.
A doctor can recommend a drug if the benefit to the mother exceeds the likely risk to the fetus.If it is necessary to have symptomatic treatment during lactation, it is advisable to temporarily switch the baby to breastfeeding.
The adversary should be taken with caution in the following diseases and pathological conditions:
- bronchial asthma;
- closed-angle glaucoma;
- diabetes mellitus.
The simultaneous use of antibiotics( according to indications for diseases of bacterial origin), mucolytic and expectorants, helps to speed up the recovery process.
For the duration of treatment it is recommended to refrain from activities requiring increased concentration of attention, including the management of vehicles and work with potentially dangerous mechanisms.
Storage and dispensing conditions from pharmacies
You do not need a recipe to purchase a prescription drugstore.
The medicine should be kept in places with a low level of humidity at a temperature not exceeding + 25 ° С.
Shelf life of the capsules is 3 years from the date of issue( it is marked on the package).
Keep out of the reach of children!
Analogs of the Assumptions
The analogues of the preparation are:
- Suprima ENT;
Vladimir Plisov, medical reviewer