Antiphospholipid syndrome in pregnancy

One of the most serious causes of miscarriage is an antiphospholipid syndrome in pregnancy. With this syndrome, there may be a violation of implantation, pregnancy, fetal development and the outcome of labor. Antiphospholipid syndrome( APS) is a condition of the female body, in which a large number of antibodies are formed, to its own phospholipids contained in the blood plasma. Thrombosis is the main complication of this pathology, especially dangerous during pregnancy.

Factors of the onset of this pathology

There are many factors in the onset of antiphosphalipid syndrome in pregnant women. One of them is a genetic predisposition to such a pathology. Important factors are the presence of a future mother of viral and bacterial infections.

In order for the pathological process to be realized, not only antibodies but also cofactors should be present in the body. When interacting with cofactors, antigen-antibody complexes are formed. There is interaction of cofactors with AFA as a result of influence of some factors of internal and external environment. This malignant formation, the effects of drugs, viral infection, etc. This leads to violations of blood coagulation functions. At the same time, the microcirculation processes are violated and the vascular walls may change.

There are such types of APS as primary, secondary and catastrophic. With catastrophic APS, there suddenly arises and rapidly develops multi-organ failure. In most cases this insufficiency is provoked by surgical interventions in the body or by infectious diseases. This syndrome manifests itself as a violation of coronary and cerebral circulation, respiratory acute distress syndrome, stupor, large vessel thrombosis, disorientation, and adrenal insufficiency and acute liver failure may develop. This is very dangerous during pregnancy.

Complications and symptoms of antiphospholipid syndrome in pregnant women

Antiphosphalipid syndrome leads to a delay in intrauterine growth, to an undeveloped pregnancy, even to fetal death in the second half of pregnancy. At the early stages of pregnancy, the fetus is damaged, which can lead to miscarriage. In the first trimester of an interesting position, the functional activity of platelets increases, the hormonal and protein-synthesizing functions of the placenta decrease. If the disease is not treated, then the activity of the blood coagulation system increases. This leads to the development of thrombosis in the vessels of the placenta, chronic hypoxia, placental insufficiency. And because of a lack of oxygen, a fetus may die.

Clinical manifestations in pregnant women of this pathology can be manifested as follows: delay in fetal development, frozen pregnancy, gestosis during pregnancy, especially severe manifestations of it - eclampsia and preeclampsia. Pregnant women may experience placental insufficiency, premature placental abruption. And also abdominal pain, headaches, weakness, fever over 37 degrees, nervousness, etc.

When pregnant, the antiphospholipid syndrome is very dangerous. It is necessary for women suffering from this pathology to be constantly observed by a specialist. The blood coagulation system, the autoimmune process, the prophylaxis and diagnosis of the syndrome should be monitored. A woman should receive timely and necessary treatment.

Treatment of APS during pregnancy

This syndrome during pregnancy is treated individually. Usually prescribe in this case, effective drugs-hormones( glucocorticoids).These drugs contribute to the normalization of blood clotting and are taken during pregnancy and some time after childbirth. Also, many other procedures are prescribed, depending on this or that case, because each woman has individual treatment.