Lamisil: instructions, indications, contraindications
Jul 09, 2018
Lamisil is a modern powerful drug designed to combat mycosis( fungal lesions, a link to the article for 21.10).It is produced in various dosage forms intended for oral administration during systemic treatment or external treatment of nails and skin.Table of contents: Active substance and pharmacy forms Lamizila Lamizil analogues Mechanism of action and pharmacodynamics Lamizila When is Lamisil given?Contraindications to treatment with Lamizil and possible side effects Duration of treatment and recommended dosages Interaction of Lamizil with other pharmacological preparations How long is Lamisil stored?
Active substance and pharmacy forms Lamizila
The active component of this antimycotic drug is terbinafine hydrochloride.
The tablet contains 250 mg of this component.In 1 g of any form for topical application contains 10 mg of terbinafine.
The tablet form is delivered to pharmacy chains in packs of 7.14 and 28 pieces.The cream and gel are packaged in tubes of 5, 15 or 30 g. The solution is sold in bubbles of 30 ml, and the spray - in aerosol cans of 15 and 30 ml.
Analogues Lamyzil for the active component:
Mechanism of action and pharmacodynamics Lamizila
Terbinafine is an antimycotic compound that is active against a wide range of fungal microflora.It has a fungistatic and fungicidal effect, that is, it destroys fungal cells and prevents their reproduction and growth of colonies.Even at low concentrations, this substance can destroy dermatophytes, as well as mold and individual dimorphic fungi.Terbinafine also allows you to cope with candidiasis, i.e., diseases caused by yeast-like fungi of the genus Candida.
The action of the active component of the drug Lamisil is aimed at suppressing the biosynthesis of sterols in the fungal cell in the early stages.It also inhibits the enzyme squalene epoxidase, which leads to a deleterious intracellular accumulation of squalene for microflora.
After taking Lamizil tablets, more than 70% of terbinafine is absorbed into the human digestive tract, and the level of bioavailability is estimated at around 50%( food intake is practically unaffected).The maximum plasma concentration is fixed 1.5 hours after taking the drug.About 99% of the absorbed terbinafine is conjugated( interacts) with plasma proteins.With external application of Lamizil, the active ingredient freely passes the dermis, accumulating in the stratum corneum.Terbinafine has the property of accumulating in sebum, so during the course of treatment, its therapeutic concentrations in the hair follicles and the sebum-rich areas of the skin are achieved.Already in the first week of antifungal therapy the drug penetrates into the nail plates.Active metabolites and unchanged substance are excreted( excreted) by the kidneys.
When is Lamisil assigned?
Note: with a diagnosed multi-colored lichen does not make sense to take Lamisil in tablets;Therapeutic effect allows you to achieve only the form for external use.
Indications for the beginning of the reception of tablets:
- mycosis of the scalp;
Tablets are prescribed for treatment of candidiasis if localization and prevalence of lesions suggest that oral therapy will be effective.
Indications for the application of gel, ointment, solution and spray Lamisil:
- mycosis stop;
- diaper rash( due to molds);
- inguinal epidermophyty;
- multi-colored lichen( caused by dimorphic fungi);
- smooth skin dermatophytosis.
Please note: dosage forms for topical topical application can be used not only for curative, but also for preventive purposes.
Contraindications to Lamisil and Possible Side Effects
The antimycotic Lamisil is well tolerated by an absolute majority of patients.Contraindication to the initiation of treatment may be only individual hypersensitivity to the active component of this drug, i.e. terbinafine.
Among the possible undesirable effects are:
- hypersensitivity reactions( allergies);
- paresthesia( impaired sensitivity);
- change in taste sensations;
- appetite impairment;
- Dyspeptic disorders;
- skin rashes;
- joint pain;
- muscle pain;
- liver dysfunction( in very rare cases).
Important: these undesirable effects sometimes develop with systemic therapy.The use of external forms in some cases can provoke allergy, itching, burning and flushing of the skin at the site of application.
Overdose( up to 5 g) may cause nausea and pain in the projection of the stomach.In such cases, gastric lavage and sorbents( for example, activated carbon) are shown.Similar tactics should be adhered to when taking external forms orally.
Duration of treatment and recommended dosages
The duration of the course of taking tablets depends on the nature of the disease.The therapeutic effect is achieved after two or more weeks of continuous treatment.
The drug is taken daily once a day.Adult patients are prescribed 250 mg each, i.e. 1 tablet per day.
A single dosage for children is determined according to the weight of the child:
- less than 20 kg - 62.5 mg;
- 20-40 kg - 125 mg;
- over 40 kg - 250 mg.
Please note: for children under 2 years of age, this drug in tablets is not usually prescribed.
Duration of the course of treatment depending on the nature of the disease and the location of the lesion( in weeks):
- fungal infection of hair and skin of the scalp - 4;
- mycosis of feet - from 2 to 6;
- shin and torso dermatomycosis - from 2 to 4;
- skin candidiasis - 2 to 4;
- onychomycosis of the hands - 6;
- onychomycosis of the legs - up to 12.
Note: with onychomycosis treatment is carried out for the time needed to grow a healthy nail.
Lamisil for topical topical application is intended for patients over 12 years of age.Problem areas of the skin before using the cream should be cleaned and, if possible, dried.It is advisable to cover the leprosy after the cream with a clean gauze.The drug is applied 1-2 times a day with light rubbing movements on the affected area and adjacent areas.
Duration of treatment:
- mycosis of the feet - 1 week( with itching and flaking - up to 2);
- shin and torso dermatomycosis - 1 week;
- candidiasis of the skin - up to 2 weeks;
- multi-colored lichen - 1-2 weeks.
The decrease in the severity of symptoms is usually noted already in the first days of therapy.With the early termination of the course, the process may recur.If the improvement does not occur within 1-2 weeks, it is necessary to conduct an additional examination in order to clarify the diagnosis.
Interaction of Lamizil with other pharmacological agents
Cimetidine is capable of potentiating the effect of Lamizil or increasing the plasma concentration of terbinafine.Rifampicin weakens the effect of this antimycotic.
Note: has data that women with parallel oral contraceptives may have cycle problems.
How long is Lamisil stored?
Packaging with the drug should be kept in a place shielded from sunlight at a temperature not exceeding + 30 ° C.
The shelf life of antimycotics is 5 years from the date of issue.
Keep out of the reach of children!
Plisov Vladimir, medical reviewer