Preparations from helminths of a wide spectrum of action and their application

The worms live with us for centuries.They have adapted to unfavorable physical factors, to the peculiarities of human life and at the most unfortunate moment are ready to enter the body and begin to parasitize.Poorly washed hands, accidentally eaten poorly processed fruit or not enough fried fish, and sometimes just a cat in the house can facilitate easy penetration of parasites to humans.To avoid serious health problems in the presence of worms in the body, it is necessary to use preparations from wide-spectrum helminths. Content:

1. How helminths get into the body and where parasitize
2. How Does Mebendazole Work
3. Features of Praziquantel
4. What parasites affectAlbendazole
5. How effective is Levamisole
6. Advantages and disadvantages of Pirantel
7. When to apply Carbendacim

How do helminths enter the bodyZm and where parasitize helminths are extremely widespread.If we talk about the number of infected at this moment, then the figure will exceed a billion.Worms penetrate the human body in three ways: independently, through food and through insects.The hookworms and nekators penetrate independently, which drill absolutely healthy skin and then spread with the blood through the body. With food contaminated with eggs and larvae of parasites, a large number of helminths enter the body, the most common of them are roundworms, pinworms, ribbons and chains. With blood-sucking insects, For example, mosquitoes and horseflies, are able to penetrate into the body of the filaria and many more rare parasites. Helminths are capable of parasitizing in all human organs, however, they are most often localized in the followingtheir bodies:

• Gastrointestinal Liver
• Light
• Brain
• muscles and lymph nodes
• body of

anthelmintics normally act on the worms located in any organs.Some drugs affect not only mature individuals, but also can destroy larvae and eggs of parasites. For more details about some types of worms, see the video: The drugs for worms with extended activity spectrum include the following drugs:

• Mebendazole
• Praziquantel
• Albendazole
• Levamisole
• Pirantel
• Carbendacim

How Mebendazole works The most popular drug is Mebendazole.The action of the drug is based on the cessation of the formation in the cell of the vital protein tubulin.As a result, the protein and carbohydrate metabolism is disrupted in the cell of the parasite, and the worm dies.In the gastrointestinal tract is almost not absorbed.The main role is played by the action of the drug in the luminal gut.Almost the entire preparation is excreted with feces in an unchanged form. Mebendazole can be used in most intestinal invasions with roundworms.It is very effective in ascariasis and enterobiosis, slightly less active against other intestinal parasites, for example, vlasoglava.Even in spite of a small systemic absorption of the drug, it also affects echinococci, alveococcus parasites in the liver and lungs.The effect persists with multiple helminthic lesions. A common dose for adults is 100 mg twice daily for 3 days.To kill pinworms, one tablet is sometimes enough.In trichinosis, when the parasite is in the muscle tissue, the drug is taken up to 10 days for 10 to 12 tablets per day. In standard doses, it is well tolerated.There may be slight pain in the abdomen, nausea, sometimes vomiting.In large doses causes serious deviations in the system of hematopoiesis and in the work of the kidneys.Urine can become scarlet because of blood, and hair completely drop out. The preparation absolutely can not be used at the diseases accompanied by formation of ulcers in an intestine because of risk of their perforation.In pregnancy, breast-feeding and children under two years is prohibited.When applying for more than 7 days, compulsory control of peripheral blood. Features of Praziquantel Praziquantel can be used in the most dangerous invasions.This is one of the most powerful drugs.The mechanism of action is based on the paralyzing of the muscles of the worms, as a result of which they can not move and perish.The medicine is well absorbed and after 3 hours creates a maximum of blood content.It is excreted with the kidneys and a small part with feces. The drug is effective against most trematodes( flatworms) and cestodes( tapeworms), including a wide ribbon, all kinds of chainworms and their larvae in the brain. The medicine is administered inside.The dose depends on the weight and age of the patient.The usual average dose of 600 mg of the drug is a single dose.It is allowed to children from 4 years old. The main undesirable phenomena when taking medication are associated with the effect on the intestines and the nervous system.In addition to pain and diarrhea, blood in the stool can also be observed.Perhaps the development of disorientation and hallucinations.All phenomena occur after the drug has been discontinued. It is not possible to use it for damage to the larvae of the porcine chain eye organ.There are no other contraindications, for life situations you can apply during pregnancy, beginning with the 2nd trimester.It is inadmissible simultaneous use of the drug and antibiotic Rifampicin. For cerebral invasions, it is not possible to take an outpatient medicine.On the day of administration and the next day, it is potentially dangerous to drive a car. What parasites are affected by Albendazole This drug has relatively recently appeared on the pharmaceutical market and has already gained popularity for a confident effect.The basis of the action of the drug is the effect on the intestine and the muscular system of the parasite.As a result, the worm can neither eat nor move and quickly dies.The drug is poorly absorbed in the intestines, but even the minimal dose in the blood is enough for a pronounced therapeutic effect.The medicine is excreted by the kidneys.With the use of fatty food, the absorption of the drug is accelerated. The drug is used in severe invasions, the main targets of the drug are listed below:

1. Glistular lung infection, including echinococcus
2. Brain lesions with
3. larvae of the brain. Intestinal invasion including ascaridosis and trichocephalosis