Artoxane is a non-steroidal anti-inflammatory drug

Inflammation and joint pain, myalgia, trauma andBurns - this is a far from complete list of diseases in which the drug Artoxan is used. Below is a detailed instruction on the use of injections of Artoxane, analogues of the drug, as well as reviews about it.

Description of the preparation

According to the instructions for use, the drug Artoxan is available as a lyophilizate of yellow-green color. Comes with the powder is a solvent - water for injection, a colorless transparent solution. The active pharmaceutical substance is tenoxicam, which belongs to non-steroidal anti-inflammatory drugs.

The drug stops the inflammatory process, removes pain and has a moderate antipyretic effect. There is also a chondroprotective effect, and with prolonged use a desensitizing effect.

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Pharmacodynamics and pharmacokinetics

The anti-inflammatory effect of arthoxane is due to the blocking of COX 1 and 2, as a result, a violation of the metabolism of arachidonic acid and the production of prostaglandins, which are the main factor of inflammation. This reduces the permeability of the capillary walls and the amount of excreta released. Stabilization of lysosome membranes interferes with the release of enzymes of damaging tissues.

There is also a suppression of the production of mediators of inflammation or their inhibition, such as the compliment system, bradykinin, lymphokines and histamine. In the zone of inflammation the level of free radicals decreases, chemotaxis and phagocytosis are suppressed.

The active principle slows the productive phase of inflammation, prevents the compaction of tissues that can form after the abatement of the pathological process. The drug acts on the pain centers localized in the brain, as a result, pain sensitivity decreases at the site of inflammation.

Pricks Artoksan according to the instructions and reviews with inflammatory-degenerative pathologies reduce articular pain, stiffness and swelling of the joints after a night's sleep, increase their amplitude of motion. With the introduction of the drug has a 100% ability to digest. The active substance easily passes through internal barriers, migrates to synovium. It has a long half-life of 60-75 hours.

Scope

Pricks Artoxan is prescribed for such inflammatory-degenerative pathologies of the musculoskeletal system, such as:

• arthritis, of various etiologies;
• Striumpell-Bechterew-Marie's disease;
• joint and muscle pain;
• lumbosatum;
• arthrosis;
• osteochondrosis;
• Inflammation of tendons, articular bags, skeletal musculature;
• periarthritis;
• pain caused by pathology of the sciatic nerve;
• neuralgia;
• injury, burns.

That is, the drug is used for all pathologies of the musculoskeletal system, which are accompanied by pain.

Contraindications to the prescription of

No injections of Artoxan should be taken if:

• is an individual intolerance to the drug, as well as other medicines belonging to the group of non-steroidal anti-inflammatory drugs;
• peptic ulcer of the stomach and 12 duodenum;
• bleeding from the digestive tract;
• blood pathology;
• cardiac, renal and hepatic insufficiency;
• aspirin bronchial asthma.

The drug should not be prescribed to patients under the age of 18, since it is not known how it will affect the growing body. With caution, injections are prescribed for patients with hypertension and diabetes mellitus.

Important! There is no data on the safety of the use of medication in pregnant women and breast-feeding. Therefore, it is worthwhile to refrain from prescribing the drug to these categories of patients. It is advisable at the time of treatment to transfer the baby to artificial nutrition.

Undesirable reactions and cases of overdose

On the background of treatment may be observed:

• bloating and discomfort in the abdomen;
• nausea;
• headaches;
• vertigo;
• itching;
• of Urticaria;
• stomatitis;
• swelling of the eyes;
• strong reddening of the skin, provoked by the expansion of capillaries;
• toxic epidermal necrolysis;
• Malignant exudative erythema;
• increase levels of urea, creatinine and "liver" transaminases.

Currently, there have been no cases of overdose. Treatment is symptomatic, since there is no specific antidote. It is necessary to ensure a good discharge of urine.

Dosage regimen

1. The lyophilizate is dissolved in water for injection and administered intramuscularly or intravenously.
2. Is it possible to dilute Novocain with Artoxane? No, so in the instructions to the drug about it is not prescribed and in the bundle to the powder is already applied a solvent.
3. Treatment is started with a daily dosage of 20 mg, which is administered once. With severe pain, the dose can be increased 2 times.
4. Supporting daily dosage of 10 mg.
5. When exacerbating gout, the course of treatment with Artoksan injections is 7-8 days.
6. For the first time 48-72 hours the drug is prescribed for 20 mg 2 times a day, in the following days the drug is administered once in a dosage of 20 mg.

Pharmacological compatibility and precautions

1. The active substance may enhance the therapeutic effect of warfarin and other anticoagulants.
2. When taken concomitantly with antihypertensive drugs, reduce their effectiveness.
3. It should not be combined with cardiac glycosides, since there is a risk of progression of heart failure.
4. With parallel administration with diuretics, there is a high probability of kidney pathology.
5. When combined with corticosteroids, there is a risk of bleeding from the digestive tract.
6. Caution should be given with oral hypoglycemic agents, lithium pharmaceutical preparations, fluoroquinolones, cyclosporine, methotrexate, other medicines of the NSAID group.
7. With prolonged therapy with injections, Artoxan controls the functioning of the liver and kidneys.
8. On the background of treatment, it is possible to prolong the bleeding, it is worth remembering during surgical operations.

Terms of sale, analogues

Arthoxan injections refer to prescription drugs. Store them at a temperature of no higher than 25 degrees in a place inaccessible to children. The pharmaceutical industry produces complete analogues of injections of Artoxane:

• Tobitil;
• The Texman.

In addition, there are synonyms for the drug Artoxane for the therapeutic group:

• Nyz;
• Ibuprofen;
• Diclofenac.

Before using the analogue, a doctor's consultation is necessary, since they all differ from each other.

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Reviews

Whom other than, instructions on the use of injections of Artoxane, patients are interested in the reviews. Patients who are treated with this drug, note its effectiveness and a quick and long anti-inflammatory, analgesic effect, as well as a short course of therapy.

Negative feedback on the injections of Artoxane are related to its price and the painfulness of the drug. But it's all individually that some people say that injections do not hurt. Despite good effectiveness, it is not necessary to undergo treatment without consulting a specialist. We suggest watching a video about NSAIDs.