Doxylamine succinate - a remedy for insomnia

Sleep disturbances of various causation widely among patients. This situation leads to sales and a large number of different hypnotics, sedatives, allows you to quickly enter a sleep state, providing its deep level( see. Hypnotics).One such remedy is Doxylamine succinate. The drug acts on the histamine receptors in the brain, provides a soft and comfortable sleep.

Background and mechanism of action

patients with insomnia( . See Chronic insomnia) wondering what - doxylamine succinate? It is an antihistamine drug that blocks the H1-type of receptors in the central nervous system, which leads to an acceleration of the sleep period, an improvement in the quality of sleep, and the preservation of its optimal duration. The use of this drug helps to maintain the physiological phases of sleep, which does not disrupt the processes of human recovery, as in the case of a number of other medications.

An additional plus of Doxylamine is the lack of influence on human cognitive functions, such as memory, ability to work. The average duration of the action is from 5 to 8 hours, which allows you to fully restore efficiency and coincides with the duration of normal sleep. The average price of Doxylamine is 200-300 rubles.

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Indications and contraindications to

According doxylamine doxylamine instructions for use is shown to people in the following situations:

• sleep disorders caused by diseases of internal organs;
• various neuroses, psychoses;
• chronic stress or acute stressful conditions;
• mental disorders, accompanied by a pathology of sleep;
• change of time zones or shift work, which requires adaptation to a new rhythm of the day;
• respiratory disorders( apnea), accompanied by sleep disturbance at night;
• sleep disorders in chronic pain in muscles, bones and other diseases.

However, as with any drug, in doxylamine there are contraindications for:

• hypersensitivity to the drug or ethanolamine derivatives;
• glaucoma in a closed-angle form;
• benign form of prostatic hyperplasia;
• urination disorder;
• tumors of the endocrine system, primarily pheochromocytoma;
• the age of the patient is up to 15 years.

Following the indications given in the instructions and contraindications for prescribing doxylamine can reduce the risk of side effects, complications of the underlying disease.

Application Doxylamine succinate

The average therapeutic dosage for insomnia is 10 to 30 mg of the drug 30-40 minutes before bedtime. Optimum duration of reception thus should not exceed two weeks. It is not recommended to use doxylamine succinate together with alcohol or other medication, depressing the central nervous system( with drugs other groups, tranquilizers, antidepressants).

In some cases, the use of doxylamine for the treatment of allergies is possible. In this case, the dosage of 25 mg with a frequency of reception is 3-4 times a day.

Important! The maximum permissible dose of the drug is 150 mg per day. The lethal dose of Doxylamine succinate varies in different people, but on average equals 20-30 tablets per dose.

Possible side effects of

Doxylamine succinate can lead to the development of side effects due to effects on the central nervous system, the main of which are:

1. Side effects associated with the blockade of choline receptors: dry eyes, impaired vision, delayed urination and increased heart rate.
2. Side effects resulting from hypnosis: possible dizziness in the morning after waking up, decreased thinking speed, increased sleepiness in the mornings, bouts of depression and mood lability.
3. Changes in the hematopoiesis system: a decrease in the number of leukocytes, anemia, a decrease in platelet count.
4. Other side effects of Doxylamine: headaches, arrhythmias, increase or decrease in blood pressure, the development of glaucoma, dyspepsia, soreness in the abdomen, icteric( yellowing) of the skin.

A wide range of side effects causes obligatory consultation with the attending physician before prescribing the drug, constant monitoring of the patient's condition at the time of admission.

Drug overdose

Overdose with Doxylamine leads to the following consequences:

• increased drowsiness, a sharp drop in mood level, increased excitability;
• convulsive syndrome, up to epileptiform seizures;
• increase in body temperature, redness of the skin;
• hypotension;
• breathing disorder;
• impaired consciousness, coma;
• dilated pupils.

Therapeutic measures include symptomatic treatment using anticonvulsants, artificial ventilation.

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The risk of developing side effects, symptoms of overdose increases significantly when using doxylamine with ethyl alcohol, atropine, barbiturates, benzodiazepines, various antipsychotics. All the data from the group of medications increase the inhibitory effect of the drug on the brain and lead to coma and respiratory failure.

Doxylamine succinate is safe with gentle use of sleeping pills, providing optimal duration and depth of sleep. Preliminary consultation with a doctor can prevent the development of side effects of the medication and choose the optimal dosage. The analogue of the drug is Dnormil. For more information about the action of the drug, see the video: