Dibasol UBF, instructions for the use of the drug, who is shown

Most antispasmodics are quite universal drugs, and are widely used in many diseases and pathological conditions.Dibazol is often used to stop the hypertensive crisis in cardiology, to treat many pathological conditions in neurology, for example, the drug is used for residual effects of such a dangerous disease as poliomyelitis, as well as peripheral paralysis of individual nerves( eg, facial).In gastroenterology, Dibazol also finds use due to predominantly myotropic antispasmodic action - it eliminates painful spasms of the stomach and intestines.

Contents:

1. Active substance of the preparation and the expected effects of its use
2. Dibazol UBF, drug application instruction
3. Indications and contraindications for use, drug interaction
4. Features of the drug in pediatrics

Dibazol - active ingredientPreparation and pharmacological effects expected from its use

The active substance of the preparation Dibazol-Bendazol is( in its pure form) yellowvaty or more grayish powder that absorbs moisture, but it dissolves in water is bad, there is a good solubility in alcohols.

This is achieved by relaxing the smooth muscles, the majority of which in the body is represented by the walls of both venous and arterial vessels, and also the wallsHollow organs of the digestive system - this effect can be obtained by reducing the calcium content in the smooth muscles.

Also one of the observed effects is an increase in the rate of transmission of electrical impulse in the synapses of the spinal cord.

The immunostimulatory activity of the drug is also noted, which is believed to be achieved due to a change in the ratio of such substances as cyclic guanidine monophosphate and cyclic adenosine monophosphate( by increasing cGMP level).This promotes the proliferation of immunocompetent cells and contributes to the normalization of their allocation of factors of mutual control.

May also cause( although a short enough) expansion of cerebral vessels.

Dibazol ubf instruction on the use of various forms of the preparation

There are three main forms of release of dibazole:

1. An adult tablet form that contains 20 mg of active ingredient.
2. Form for enteral use in children containing 4 mg of Bendazole.
3. Ampoules for injection 2 ml each.

Methods of taking the drug:

1. When taking the medication inside the dose for an adult patient is up to 50 mg, depending on the patient's body weight and the severity of the condition.The drug, given its fairly short-term action, should be used 2-3 times a day.
2. The pathology of the nervous system requires several different dosages - the drug in such cases is prescribed at 5 mg or once a day, or at all in a day.
3. In children, the dosage directly depends on the age - up to 1 year, 1 year is prescribed, up to 3 years - no more than 2 mg, up to 8 years - 3 mg, up to 12 years - 4 mg, for children over 12 years, the drug is prescribed in a dose of 5 mg.Admission in all age groups is single.
4. Intravenous and intramuscular administration of dibazol can be carried out at a dose of 2-3 mg, the maximum single dose for such routes of administration of the drug should not exceed 5 ml.

Avoid prolonged use of the drug, especially in patients of older age groups, as this can lead to a significant deterioration of the electrocardiogram.

Features of interaction of dibazol with other drugs, indications and contraindications to the use of

The interaction with such drugs is particularly pronounced:

1. Diuretics and antihypertensives, in the case of use, simultaneously enhance the hypotensive effect of each other.
2. With the use of dibazol simultaneously with drugs from the group of beta adrenoblockers, it is possible to prevent the growth of the total peripheral resistance of the vessels caused by the latter.
3. Drotaverin( a drug much more widely known as a No-Shpa) together with Dibazol mutually reinforce the spasmolytic effect of each other.
4. When applied simultaneously with a non-selective adrenoblocker Fentolamine, the hypotensive effect of Dibazol is enhanced.

Indications for the use of dibazol are:

1. Arterial hypertension, both primary and secondary.
2. Management of hypertensive crises.Angina pectoris caused by angiospasm.
3. Stomach ulcer, duodenal ulcer, pylorospasm.
4. Renal colic.
5. Polyneuropathies, including facial nerve lesions.
6. Long-term sequelae of the nervous system after a previous history of poliomyelitis.
7. Abdominal pain( not yet diagnosed).
8. Various peripheral vascular diseases.

Contraindications to the use of dibazol:

1. Intolerance to Bendazole.
2. Severe arterial hypotension.
3. Convulsive syndrome.
4. Intestinal bleeding.
5. With significant impairment of kidney and liver function.

The most common side effects of the drug include allergic reactions.With the introduction of large doses, there may be an increase in sweating, a headache, a feeling of heat.

Application of dibazol in pediatric practice

Relatively low incidence of side effects and sufficiently high safety of the drug allow it to be used, including in pediatrics.Especially often it is used to treat newborns from the effects of birth injuries, which are accompanied with fetal hypoxia, which leads to a variety of neurological symptoms - to muscle hypertension, chin tremor, tremor, sleep and wake rhythm disorders, and intracranial pressure.

With all the above symptoms, Dibazol can be used, in which case not only its spasmolytic effect is used, but also the ability to improve cerebral circulation.Also, the use of Bendazol in childhood can be justified in colic, as well as in cases of too frequent colds - in this case the immunostimulating effect of the drug is used.

Dibasol is a fairly popular and frequently used drug.He finds application in the most diverse branches of medicine - in cardiology, neurology, immunology, pediatrics and many others.This is provided by multifaceted positive effects, as well as a sufficiently high safety of the drug( except for patients of older age groups in the case of prolonged treatment.) Despite all the safety of the drug, it is necessary to consult the appropriate specialist before starting its use, only then treatmentWill be effective, and the likelihood of undesirable effects will be minimal.

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