Gilbert's Syndrome

Gilbert syndrome( Gilbert's disease, hereditary pigmentary hepatosis, Gilbert's hyperbilirubinemia, benign familial non-hemolytic hyperbilirubinemia, fermentopathic hyperbilirubinemia) is a congenital disease that is caused by a mutation of the gene encoding the uridine diphosphate enzyme.

Syndrome or Gilbert's disease is a congenital disease inherited by an autosomal dominant type. According to statistical data, about two to five percent of quite healthy men aged 20 to 30 years are found this disease( men are sick four times more often than women).The onset of the development of Gilbert's syndrome in most cases falls on adolescence and continues throughout life.

Gilbert syndrome is characterized by the following factors:

- Partial insufficiency of glucuronyltransferase( activity of about thirty percent of the norm)

- Moderate increase in bilirubin in the blood

- Reduction of elevated bilirubin due to phenobarbital

- Absence of other morphological or functional changes in the liver

- Autosomal dominantType of inheritance

Symptoms of

The most characteristic symptoms of Gilbert's syndrome are:

- Discomfortable feeling

- In some cases, there is an increase in liver size

Factors that provoke the manifestations of this disease can be:

- Taking certain medications

- Strengthened physical activity

- Various operations

- Alcohol consumption

- Difference from the diet

- Colds

In the middle of the forecourtThe cases of Gilbar's disease, in patients there is a lack of appetite, nausea, belching, meteorisms, stool disorders. Occasionally, there are unpleasant sensations in the liver.

Diagnostics

total bilirubin measurements under Gilbert syndrome fluctuate at the level at from 21 to 51 mol / L, and under the influence of diseases or physical stress can increase to 85-140 mmol / l.

Specific diagnostic tests with Gilbert's syndrome

sample with

After twenty-four hour fasting or starvation after sorokavosmichasovoy low calorie diet( no more than 400 kcal per day) bilirubin concentration in blood serum increases by 50 - 100%.Bilirubin is determined in the morning on an empty stomach on the day of the beginning of the test, and then after two days.

sample with phenobarbital

Phenobarbital leads to lower bilirubin levels, through stimulation of enzyme activity glyukuroniltrasferazu.

There are also other types of samples: a sample of bromsulfalein and a sample with nicotinic acid.

Additional diagnostic procedures include computed tomography or ultrasound of the liver, needle biopsy and determination of liver enzymes in the blood serum

Treatment Special Treatment of Gilbert's syndrome is usually not carried out, as this is not considered a disease, and the individual characteristics of the organism.

During the exacerbation, vitamin therapy is prescribed, taking cholagogue and sparing diet No. 5.But even if this is not done - manifestations of jaundice and so pass on their own.

The main importance is the constant adherence to the diet, work and rest. It is advisable to exclude the use of alcoholic beverages and fatty foods, avoid physical overloads whenever possible.

An increase in bilirubin appointed reception sorbent "Sorbovit-To" cure, and then reduce it must go on prophylactic

forecast

forecast at Gilbert's syndrome is considered to be quite favorable, as it is considered one of the variants of the norm and does not affect the life expectancy. People with this syndrome are almost healthy, and therefore do not need special treatment.