Azilect - a new modern medicine for Parkinson's disease

Parkinson's disease, tremor paralysis, idiopathic paroxysmic syndromeAll this is the name of one pathology. After the appearance of the first signs of ailment, after a few years the patient without proper treatment can become disabled or even die. It is about the newest medicine of modern times, Azilekt, which is used in this dangerous disease will be discussed in the article.

Description of the drug

Azilekt is manufactured by the Israeli company Teva in the form of round tablets of white or practical white color. They have a facet, on one side they have engraved "GIL 1".The active pharmaceutical substance of the drug is rasagiline mesylate, which selectively irreversibly blocks MAO-B.As a result, the concentration of dopamine in the central nervous system increases and the level of free radicals decreases, which accumulate in a large amount in the case of a tremor paralysis.

Since the drug raises the level of dopamine, it is possible to use azilekt in the treatment of sbn( restless leg syndrome) pathogenesis, which is associated with impairments in dopaminergic systems.

Also active substance prevents neuronal damage to the central nervous system. When taken orally, the drug is rapidly absorbed from the digestive tract. The highest concentration in the blood is observed after 30 minutes. When eating fatty foods this time increases. Passing the hepatic barrier the drug is completely metabolized. The drug is excreted mainly with urine, and only a fifth of the dose taken with feces.

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Indications and restrictions for the prescription of the drug Azileth

Azilekt tablets are prescribed either as mono- or polytherapy in combination with levodopa-based medications to treat tremor paralysis. According to the instructions for use Azilect is contraindicated, if observed:

• individual intolerance;
• therapy with other medications and BAA blocking MAO, including St. John's wort, pethidine, the difference between taking these drugs and Azilect tablets should be at least 2 weeks;
• mean and severe hepatic impairment;
• age is under 18 years.

With caution, it is necessary to prescribe Azilect tablets for mild hepatic insufficiency, with concurrent treatment with medications that affect the central nervous system and a strong isoenzyme blocker CYP1A2.

At pregnancy and feeding! The drug is allowed to be given to pregnant women if the benefit to it outweighs the risk to the child. When breastfeeding naturally, it should be taken into account that the active substance suppresses lactation, whether it penetrates into breast milk.

The drug is prescribed 1 mg 1 time per day. You can take it regardless of food. Patients of the older age group, as well as those suffering from kidney disease, do not need to adjust the treatment regimen.

Undesirable reactions and cases of overdose

Instruction Azilect says, against the background of treatment the following undesirable phenomena are possible:

• flu, fever, general malaise;
• skin cancer;
• leukopenia;
• allergy;
• depression, hallucinations;
• decrease in appetite, weight loss;
• headaches;
• disorder of cerebral circulation;
• dizziness;
• conjunctivitis;
• flatulence, dyspepsia, dry mouth;
• angina, myocardial infarction;
• runny nose;
• dermatitis, vesiculo-bullous rash;
• pain in the musculoskeletal system, inflammation of the joints;
• urge to empty the bladder;
• sharp pressure drop;
• impulsive personality disorder.

In case of an overdose, hallucinations, confusion, hypo- or hypertension may occur. Therapy is symptomatic, since there is no specific antidote.

Pharmacological interaction and precautions

Do not take the drug Azilect with other monoamine oxidase blockers, as in this case the probability of developing a hypertensive crisis increases. The likelihood of undesirable effects increases with parallel administration of the drug with tricyclic and four-cycle antidepressants, pethidine and sympathomimetics, including for nasal administration.

Caution must be exercised when taking Azilec concurrently with drugs that block the isoenzyme CYP1A2, since in this case the concentration of rasagiline in the body may change. Therefore, it is worth informing the doctor about all medications and dietary supplements.

It is necessary to exercise special care when driving a car and when working with dangerous mechanisms, as against the background of treatment there may be dizziness and a sharp drop in pressure.

Drugs-synonyms

Currently, there is no complete analogue of the preparation Azilect. There are only analogues of Azilekt on the therapeutic group:

• Segan;
• Yumeks;
• Niar;
• Eldepril.

Prior to the replacement of Azilekt with a similar medication, a specialist consultation is required, as each of them has its own application features.

Reviews about the drug Azilekt

About the tablets Azilect reviews can be found both positive and negative. Negative reviews of the drug are associated mainly with its high cost and unwanted reactions appearing against the background of therapy.

There are also negative reviews that the medicine did not help and the patient's well-being only worsened. But there are also many reviews of the fact that the symptoms of trembling paralysis have disappeared against the background of treatment.

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Storage and distribution conditions

The drug should be stored in a place inaccessible to children, at a maximum temperature of 25 degrees. The drug is dispensed from the pharmacy strictly on the prescription form. Tablets Azilect can not be taken without the recommendation of a specialist, as they can cause serious adverse reactions. Only a doctor can choose the optimal therapy regimen. We offer a video about Parkinson's disease and its modern therapy.