Who is prescribed the drug Gababamma

active substance medications Gabapentin belongs to a group of funds for epilepsy therapy. Detailed information about Gabagamma is contained in the instructions for use. The drug is in the form of capsules with a content of 100, 300 or 400 mg of the active ingredient. Pharmacological action

Gabagamma

Gamma-aminobutyric acid is involved in the transmission of nerve impulses and has a structure similar to gabapentin. But it does not act on GABA receptors as drugs from the group of barbiturates, valproate, benzodiazepines, GABA uptake inhibitors, agonists and prodrugs thereof.

In studies established that Gabagamma connected with certain voltazhzavisimymi pores and reduces the flow of calcium ions are involved in the formation of neuropathic pain. Also, the effect is manifested in a decrease in glutamate-dependent apoptosis of neuronal cells, increases the production of GABA.It does not contact the receptors of other substances and does not reduce their effectiveness.

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Metabolism

The blood content rises to a maximum of 2-3 hours after the capsule is drunk. With an increase in the dose, bioavailability decreases. Parallel food intake does not affect the absorption of the drug. The active substance does not conjugate with plasma proteins, freely passes into the female milk, cerebrospinal fluid. In patients with epilepsy, the concentration in the cerebrospinal fluid reaches 20% of the plasma concentration.

Does not induce enzymes of microsomal oxidation in hepatocytes. It is excreted through the kidneys in the initial state. Half-life is not associated with the dose taken and takes 5-7 hours. In patients with renal failure, the time increases.

Important! The drug Gababamma is excreted from the plasma by hemodialysis. Therefore, these patients are revised dose.

Metabolism in children is not fully investigated. But when choosing a dose per kilogram of body weight in children over 5 years of age, the distribution and elimination rates are similar to adults.

Indications and contraindications to manual

Gabagammy calls several states to use drugs: elimination of pain from diabetic neuropathy and postherpetic neuralgia in adults for the treatment of partial seizures with secondary generalization in adults and children from 12 years.

Contraindicated in acute inflammation of the pancreas, individual intolerance to components, children under 5 years.

Assignment method Gababamma

Take capsules, not paying attention to food intake. Begin with a minimum concentration of 300 mg, gradually bring it to the desired level, which was determined by the doctor. The maximum dosage can reach 3600 mg per day.

In the treatment of seizures, it is unacceptable to increase the interval between doses of more than 12 hours. In case of kidney diseases, the dose is reduced. And patients on hemodialysis are given a drug every 2-4 hours. To cancel the drug, the dosage is gradually reduced within 7 days.

You can use not the preparation of Gababagma, but analogs. They are represented by the following medicines:

• Gabapentin or Convalis( manufactured by Russia);
• Katen( Croatia);
• Tebantin( of Hungarian origin);
• Neuronin( USA).

The price of Gabagamma from different manufacturers may differ by a factor of 2.Side effects

Gabagamma

undesirable manifestations of drug action appear with prolonged use or repeated exceeded the recommended dosage. Gabagamma affects different groups of organs.

Cardiovascular effects are manifested by a jump in blood pressure, heartbeat. For the digestive system, the opposite states are possible: constipation, diarrhea, flatulence, anorexia, a significant increase in appetite, dyspeptic manifestations, dryness in the oral cavity, elevation of ALT and AST, icterus of the skin, liver damage, inflammation of the pancreas. Hemopoiesis corresponds to a decrease in the level of leukocytes and platelets, frequent bruising.

Disturbances in the nervous system are manifested by dizziness, headaches, hyperkinesis. The reflexes may intensify or disappear, there may be a disturbance in coordination of movements, rhythmic twitchings of the eyes, speech becomes difficult, consciousness becomes confused, a feeling of crawling creeps appears, fatigue is increased.

In more severe cases, memory loss, sleep disturbance, depressive states, slowing of thinking, emotional instability, hostile attitude, aggressiveness and hallucinations develop.

Some people develop bronchitis, pneumonia, shortness of breath, easy to attach infections of the upper respiratory tract. Possible development of urinary tract infection, urinary incontinence and kidney failure.

Acne, rashes, itching appear on the skin. Sometimes there is a rise in body temperature, weight gain, swelling, pain sensations of different locations.

Manifestations of an overdose resemble intensified side effects. But if you follow the instructions for the use of Gabagamma, there will be no undesirable effects.

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Special instructions

Joint use with other medicines for the treatment of seizures of gabapentin shows no mutual influence. Medicines to reduce the acidity of gastric juice with aluminum in the composition reduce the bioavailability of Gababamma. Naproxenum increases the absorption of gabapentin.

Important! Pregnant women are prescribed a drug if the risk from the appointment is less than the effect of treatment. Breastfeeding and taking gabagamma are incompatible.

Children under 12 years are appointed with caution, as well as people over 65. The drug affects the management of cars and complex equipment, it is better to give up work that requires a lot of concentration.

Reviews and price

These are the main provisions of the instructions for the use of Gababam, the price and reviews for the drug are different. The cost varies from 350 to 1090 rubles in different regions, depending on the amount of active substance and the number of capsules in the package.

Reviews of real patients are not the same. Most agree that in the complex treatment of seizures, Gabagamma has the necessary effect. The frequency and severity of side effects depends on the initial level of health.