Hyperinsulinism

Hyperinsulinism( Hypoglycemia) is an endocrine disease characterized by attacks of significant reduction in blood sugar( hypoglycemia).At the same time, not only does the sugar level decrease, but there is a decreased processing of glucose by the brain tissues. These processes occur because of a relative or absolute increase in insulin levels. In most cases, the disease develops in the age range from 25 to 60 years and often is hereditary

causes of hyperinsulinism

Hyperinsulinism distinguish :

- Primary( pancreatic, absolute), which is caused by hyperplasia of the islets of Langerhans, adenoma or

cancer - Secondary(Extra-pancreatic, relative) associated with inadequate production of counterinsular hormones or with lesions of the nervous system

The causes may be :

- Significant increase in the number of beta cells located in the pancreas area

- Neoplasms of certain areas of insulinoma

- Diseases and disorders of the central nervous system

- Insufficient production of contrinsular hormones( adrenaline, glucagon, cortisol)

- Connective tissue-developing neoplasms, Which actively process glucose

- Developing outside the pancreas tumors that produce substances similar to insulin

is the cause of the disorder Hyperinsulinism adequate functioning of the central nervous system symptoms

Seizures hyperinsulinism in most cases occur after prolonged fasting, or in the morning on an empty stomach. The development of functional hyperinsulinism leads to long-term carbohydrate starvation. Also, the causes of the development of this disease can be mental and emotional experiences and shocks and physical overstrain. In women at the initial stage of the disease, clinical signs can be observed only in periods before menstruation.

The attack begins with a feeling of weakness and severe hunger, a person begins to sweat profusely. There is an uneasy feeling and tachycardia, in the legs and hands there is a shiver, the skin of the face pales noticeably. There are sensations of numbness and tingling in the body, double vision appears. Due to the extremely agitated psyche, a person is able to commit unmotivated acts. Due to the disorder of the innervation of the speech apparatus, speech is disrupted, disorientation in space develops. If the attack of hyperinsulism does not stop in time, the person falls into a swoon and beats in cramps, in its manifestations very similar to epileptic seizures. Possible the onset of insulin coma.

In inter-interval intervals, there are violations of the central nervous system: depression, indifference, sensitivity disorders, loss of efficiency, numbness and tingling of limbs, mental imbalance, memory impairment. Of - the need to regularly eat often enough, patients begin to appear different degree of obesity treatment

insulinoma and tumors of other organs, provoking hypoglycemia treated only operatively. With hyperinsulinism of a functional nature, the administration of corticosteroids and fractional nutrition with a limited carbohydrate content are indicated. Hypoglycemic attacks are stopped by intravenous injection of 40-60 ml of 40% glucose solution.

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