Nervous-arthritic diathesis

Nervous-arthritic diathesis is an altered reactivity of the nervous system caused by the inheritance of the morphofunctional features of the organism that determine the disruption and synthesis of purine nucleotides. To date, neuro-arthritic diathesis affects about 5% of children. And the number of children with neuro-arthritic diathesis tends to grow. In the future, these people are ill with gout, obesity, nephritis, urolithiasis, diabetes mellitus, cholelithiasis, early atherosclerosis. Urine acid is responsible for this. Salts of uric acid are deposited in various organs and tissues, disrupting their functioning. Uric acid is a kind of "dope", because it has a caffeine-like effect, therefore, children with neuro-arthritic diathesis have a high IQ.The US conducted research among students and teachers in a blind manner, which resulted in a direct link between a high IQ and a high level of uric acid.

Causes of neuro-arthritic diathesis

Heredity plays a major role in the formation of neuro-arthritic diathesis in children. If you look at the pedigree, then, of course, there are cases of urolithiasis, gout, obesity. Suffers, as a rule, the father's line. It has been established that the reason for the increase in uric acid is a recessive gene attached to the X chromosome. This gene encodes hypoxanthine-guanine-phosphoribosyltransferase, an enzyme involved in the exchange of uric acid and hypoxantins as a whole. This explains the excessive formation of uric acid after consuming products rich in purine bases.

The association of a defective gene with an X chromosome explains the high incidence of male involvement in neuro-arthritic diathesis. An important role in the development of neuro-arthritic diathesis is played by the environment, namely, the fact of overeating, stress. Staying pregnant in an unfavorable ecological setting, especially in areas contaminated with radioactive waste, can also lead to the development of this pathology in the child.

Symptoms of neuro-arthritic diathesis

Since birth, neuro-arthritic diathesis in children manifests itself as hyperexcitability of the nervous system. Such children from an early age are registered with a child neurologist. The breastfeeders gain weight poorly, fearful, restlessly asleep. This is due to the accumulation in the blood serum of the decomposition products of nucleic acids( purines) and uric acid, which cause excessive irritation of the central nervous system. For the same reason, among children with neuro-arthritic diathesis a huge percentage of geniuses or, so-called, "child prodigies".

Neuro-arthritic diathesis in children provokes premature maturation of the nervous system. Children before their peers master speech, have an excellent memory, curious, early start to read. At the same time, they have nightly fears, nervous tics. With age, excitability only increases. In the morning there is a smell of acetone, it is similar to the smell of stale fruit, from the mouth. A complete clinical picture unfolds in children at the prepubertal age. Young children may suffer from anorexia. They are asthenic type of physique.

At pubertal age, the situation is radically changing. Adolescents differ in increased appetite and at a high rate gain weight up to one degree or another of obesity. There are 2 syndromes: syndrome of metabolic disorders and neuropsychic. The most vivid manifestation of the syndrome of metabolism is ketoacidosis. It manifests itself in attacks( crises) of indomitable acetonemic vomiting. The attack looks like this: vomiting starts abruptly, it is indomitable, there is a smell of acetone;fever;Abdominal pain cramping;headache. Vomiting can last up to several days. The result of this attack is metabolic acidosis and dehydration( decreases the number of urination, skin and mucous membranes dry, skin elasticity is reduced, the turgor of tissues is reduced, facial features are sharpened, weight is reduced).Metabolic acidosis is manifested by a decrease in blood pH, noisy frequent breathing( Kussmaul breathing), which is a respiratory compensation of acidosis. During the crisis, the level of ammonia, ketone bodies, uric acid sharply increases. In many ways, the clinical picture of the crisis is similar to ketoacidosis in diabetes mellitus.

In the case of neuro-arthritic diathesis, there is a relative deficiency of glucose, but there is an abundance of proteins and fats that came with food. The body tries to use them as an affordable source of energy. But in the situation of the broken chain of exchange of these substances, can not cope with the task. As a result of the decomposition of this material, an increased amount of fatty acids, glycerin, is formed. Increased intake of free fatty acids into the liver leads to an increase in the production of ketone bodies and triglycerides, which leads to an elevated level in the blood. As a result of the breakdown of proteins, the levels of urea and nitrogen in the blood increase. Metabolic acidosis and an increased number of ketone bodies in the blood of the body tries to compensate for the periphery. Hence vomiting, a pathological type of breathing. The duration of the crisis can be up to 5 days. Vomiting stops as suddenly as it begins.

Provoke such attacks of stress, inaccuracies in the diet( against the background of a deficiency of easily assimilated carbohydrates excessive consumption of products rich in purine bases).By adolescence, neuro-arthritic diathesis in children is leveled. Manifestations of it become not so bright, but the features of the metabolism of uric acid do not overgrow. They are transformed into urolithiasis, cholelithiasis, arthritis, gout, obesity, early atherosclerosis, neuralgia.

Among other things, a large percentage of children complain of pain in the joints, although gout for childhood is not typical. The pains in the joints are short-lived, disappear spontaneously. Perhaps, also the development of bronchospasm with the further development of bronchial asthma. Asthma, as a rule, manifests itself in mild forms and is well amenable to correction by drugs. Bronchospasm, intestinal, renal, hepatic colic, constipation, pain in the heart are related to the manifestations of the spastic syndrome. These children are noted for the lability of blood pressure with a tendency to increase it. In this connection, they are observed in a neurologist with a diagnosis of vegetative-vascular dystonia.

There may be a skin syndrome. Development of it is noted in children, beginning at the age of 10 years. It appears in the form of various kinds of allergic reactions. This may be eczematous skin lesions, urticaria, atopic dermatitis, neurodermatitis, life-threatening conditions, such as Quincke's edema. Without observing the appropriate diet, the skin syndrome is hard to correct.

Diagnosis of neuro-arthritic diathesis should include the collection of a detailed anamnesis. It is necessary to find out what diseases suffer or suffer relatives, to establish the characteristics of the development of the child from birth to the present age, as the development of symptoms. Surrendered "on-duty" tests( general urine analysis and a general blood test).In the general analysis of urine, an increased level of uric acid is detected, shifting the pH to the acidic side. During the crisis, a positive test for acetone is noted. In the general analysis of blood during an attack of acetone-negative vomiting, signs of dehydration of the body can be determined: high hemoglobin, erythrocytosis, leukocytosis, accelerated ESR.The level of glucose in the blood is reduced. In the biochemical analysis of blood, there is an increase in the level of uric acid. Early diagnosis of neuro-arthritic diathesis helps to correct the child's condition as soon as possible and improve the quality of his life.

Treatment of neuromuscular arthritis diathesis

Hospitalization of patients in a ketoacidotic crisis should be immediate. Treatment of neuro-arthritic diathesis during a crisis is the correction of dehydration and ketoacidosis. Infusion therapy includes intravenous drip injection of 5-10% glucose solution, physiological solution, 4% sodium hydrogen carbonate solution, 5% solution of ascorbic acid( 1-2 ml per day), hepatoprotectors. If the child does not refuse the proposed liquid, orally give solutions such as "Oralit", "Glucosolan", "Regidron".With ketoacidotic vomiting for the first 12 hours, hunger is prescribed.

To prevent crises, diet therapy is recommended for neuro-arthritic diathesis, it is necessary to develop a mode of work and rest for a child, use hardening procedures, spend more time walking and sit as low as possible in front of a television or computer screen. In summer, trips to the pioneer camp, village are recommended. If in the near future the child is to experience a "planned" stress, for example, an exam or an increase in physical activity, you should always keep alkaline mineral water, sweet fruit, tea, compote or dried fruit. They will give the body an additional source of easily assimilated carbohydrates, reduce the formation of ketone bodies in the blood and will not allow the acetone crisis to develop.

At the first sign of ketoacidosis, a child is given a sweet drink every 15 minutes. For these purposes, you can use 5% glucose solution, fruit juices, tea, compote, alkaline mineral water. Feed the child follows food rich in easily assimilated carbohydrates, but depleted animal fats. This is the case when you can safely recommend liquid manna porridge, bananas, milk, kefir, vegetable purees are also suitable. To remove ketone bodies, a cleansing enema and gastric lavage are recommended.

If the neuro-arthritic diathesis occurs with frequent attacks of acetonemic vomiting, then such a child is given courses of vitamins B 12;Preparations violating the synthesis of uric acid( Allopurinol intake is allowed from 10 years);preparations interfering with the concentration of ketone bodies( Calcium pantothenate is allowed from the age of 1 year);Drugs enhancing the excretion of already produced uric acid( Etamid);phytotherapy( infusion of valerian root, tincture of motherwort as many drops per reception as for years to the child), hepatoprotectors( LIV-52 is allowed for children from 6 years of age).All medications should be used in the age-appropriate dosage.

Diet for the neuro-arthritic diathesis

Diet therapy for neuro-arthritic diathesis is able to correct the manifestations of purine metabolism disorders. The products included in the ban list are rich in purine bases: coffee, strong tea, chocolate, sardines, cocoa, a family of legumes( soybeans, peas, beans), Broths( meat, fish), pates, by-products( brains, liver, kidneys), herring, sweet fizzy drinks. It is desirable to exclude spinach, radish, cauliflower, rhubarb, tomatoes, sorrel, sausages. Substantially restrict the consumption of animal fats( vegetable fats are allowed), sugar, mushrooms( champignons, chanterelles, white fungus), poultry, walnuts, almonds, hazelnuts, animal meat( rabbit, beef, lamb, veal), confectionery,sea ​​fish in any form( salmon, cod, flounder, mackerel, haddock).

The basis of the diet should be: products from rye flour, cereals from cereals containing starch( oatmeal, millet, barley, barley), all kinds of vegetables( potatoes, zucchini, eggplants), one egg per day, fruits( apricots, apples), milkand dairy products, cheese. Because children suffer from a decrease in appetite, it is not necessary to use violent methods to feed a child, but, if possible, long interruptions between meals should be avoided.