Anaprilin: instructions for use, dosage, contraindications and side effects

Anaprilin, the instructions for the use of which comes with the medicine, has the following properties: eliminates ectopic heart rhythm disturbances, prevents angina attacks and other cardiac ischemic disease. Also, the drug reduces the work of the sinus node, as a result of which it inhibits the process of the myocardium, various ectopic centers, stabilizes membranes and reduces heart rate, decreases AV permeability rate, reduces myocardium and its absorption oxygen.

Let's see if Anaprilin lowers blood pressure or not. Through the application Anaprilina and providing a hypotensive effect on the work of the heart, a positive result is achieved and everything stabilizes after completion 2 weekly course. The active excitability of the system decreases and blood agents increase their movement accordingly.

Uterine contractions (involuntary, provoked by the myometrium) become stronger, which in every possible way prevents bleeding during labor and the period after surgery.

The bronchial tone increases, which contributes to the sedative effect. The pressure in the eyes decreases due to the suppression of the products of liquid moisture in the eye chamber, while it does not affect the size of the pupil and accommodation.

Protranol, which is part of the drug, improves heart rate, has an antianginal and hypotensive effect due to the suppression of β-1 and β-2 adrenergic receptors. Reduces the contraction of the myocardium, the need for oxygen, the release from the heart. Reduces pressure in arteries and increases peripheral vascular resistance. In addition to the main functions, the drug, due to the blockade of β-2 receptors, increases bronchial tone, uterine contractility, stops bleeding after childbirth or surgery, activates the work of secretors in the system digestion.

According to the instructions for use, Anaprilin passes into the blood in a very short period of time. The half-life of propranolol is about 5 hours, with a long intake it reaches 12 hours, until all Anaprilin is excreted. The instructions for use describe that the active substance is released with the help of the kidneys in metabolic form (up to 90%), and the rest remains in its primary state.

Anaprilin - release form and indications for use

Anaprilin, the release form of which is of several types, is sold in the form of tablets of 10 and 40 mg:

Classes for bulleted and numbered lists:

• in packs of 1 cell of 10 pcs .;
• 5 packs in paper boxes;
• in colored glass jars, 50 pcs. Anaprilin tablets (release form 1 glass jar is equal to 1 paper box).

The content of 1 tablet form of release is 10 or 40 mg of propranolol hydrochloride. Additional components: talc, corn starch, hypromelase, colloidal silicon dioxide, calcium stearate, cellulose microcrystals. During storage, you should avoid illuminated and humid places with a temperature of no more than 25 ° C. No access for children.

Propranolol stops b1- and b2-adrenergic receptors, acts on membranes, suppresses the work of the sinoatrial node, the formation of ecropic sites, in the atrium, atrioventricular node and in the ventricles.

Reduces the excitatory process in the atrioventicular attachment to the Kent's bundle, mostly in the anterograde side.

Reduces the work of heart contractions, the need for myocardium in oxygen. Reduces cardiac output, renin secretion, arterial pressure, renal clearance and glomerular filtration. It has a suppressive effect on the baroreceptor arch of the aorta and a decrease in pressure in the arteries. It makes inactive lipolysis in adipose tissues, prevents the formation of new fatty acids.

It has a suppressive effect on lycogenolysis, glucagon and insulin secretion, converts thyroxine into triiodothyronine. Increases uterine contractility and muscle tone in the bronchi, secretory work in the digestive system.

In ischemic patients, it reduces the frequency of angina attacks, the need for nitroglycerin, and increases the ability to exercise physical nature. The cardioprotective effect of the drug reduces the possible risk of myocardial infarction and unexpected death by 20 to 50%.

After a single use of propranolol, a decrease in diastolic and systolic pressure in the arteries has been proven, both in the horizontal position and in the vertical position. A positive hypotensive effect is seen by the end of the course of the taken Anaprilin pill.

The indications for the use of the drug are extensive. It is used for cardiac ischemic diseases, angina pectoris, abnormal heart rhythm, as well as for tachycardia provoked by thyrotoxicosis. To prevent severe migraine symptoms. Anaprilin is indicated for use as a medicine in a variety of therapies.

Anaprilin: dosage for various diseases

Anaprilin, the dosage of which is calculated on the type of disease, should be taken before meals (interval from 10 minutes to half an hour), washed down with the usual volume of liquid for a person.

A specific dosage and frequency of taking this medication is prescribed by a doctor who determines the amount of time of treatment with the drug, depending on the age of the patient and the possession of the main and accompanying diseases.

On average, the course of treatment for diseases of the cardiovascular system lasts about a month. When indicated, the course should be repeated, after waiting for a break in 1-2 months.

The following will be the average dosage for the use of Anaprilin for adults for various diseases:

• Arrhythmia: 10-30 mg three or four times a day.
• Arterial hypertension: Initially, Anaprilin, the dosage of which is 80 mg, should be taken twice a day, after which, if necessary, the daily dose should be increased to 320 mg.
• With migraine: the dose of the drug per day can vary from 80 mg to 160 mg.
• With angina: in the initial 3 days of admission - 20 mg 4 times a day, on the following days - 40 mg 3 times a day, and in the fourth dose - 20 mg. From day 7, the drug is taken at 40 mg four times a day. Anaprilin for tachycardia: how to take - 40 mg each 5-6 once a day.
• Postponed myocardial infarction: the drug should be taken 40 mg 4 times a day. With a certain strict prescription from a doctor, a daily intake of 0.25 mg-0.5 mg per 1 kg of weight may be prescribed for children over three years old.

During pregnancy, Anaprilin is prescribed by a specialist if the drug does not harm the health of the fetus. Also, during the course of treatment with this drug, strict monitoring of the condition of the fetus is carried out. Three days before the onset of labor, Anaprilin is categorically contraindicated.

The abstract describes in detail that the drug can have a detrimental effect on the fetus as bradycardia, hypoglycemia and intrauterine growth retardation. In a very rare case, premature birth or fetal death. When taking this medication during breastfeeding, the effective substances can be absorbed into breast milk, which is why breastfeeding should be discontinued.

When the drug is taken together with hypoglycemic drugs, the effect of the latter is enhanced, which can contribute to the development of such a deviation as hypoglycemia.

Taking the drug and MAO inhibitors together, it contributes to the manifestation of side effects with a combination of funds.

The use of Anaprilin, coupled with Propranolol due to arrhythmia, which was facilitated by the intake of digitalis, there is a risk of increased bradycardia.

When taking Anaprilin with drugs for inhalation anesthesia the chances of an increase in the functioning of the myocardium and an increase in such a deviation as arterial hypotension increase.

When using the drug together with Amiodarone there is a risk of detecting such a violation as bradycardia or hypotension, cessation of heart activity, life-threatening heart rhythm disturbance.

Sharing with Verapamil may contribute to the appearance of bradycardia, hypotension or dyspnea, and an increase in concentration may also be observed medicinal substances in the blood and weakening the excretion of propranolol, due to the deterioration of its disintegration in the liver due to the action Verapamil. Moreover, propranolol is not able to affect Verapamil.

The use of Anaprilin and Hydralazine helps to increase the concentration of medicinal substances Propranolol in the blood. There is also a possibility of impaired blood circulation in the liver and a slowdown in its enzymatic reaction, which can slow down the action of propranolol, which Anaprilin tablets contain.

The abstract describes that when taken together with drugs, glibenclamide, glyburide, chlorpropamide, tolbutamide can be inhibited by propranolol. Due to exposure to sulfonylurea drugs, the production of insulin by the pancreas is weakened. exposure to beta-blockers, which can cause an obstacle in the growth of hypoglycemic impact.

Joint reception of Anaprilin and Diltiazem promotes an increase in the cumulation of propranolol in the blood, due to the action of Diltiazem on it and a slowdown in its enzymatic reaction. There is a likelihood of a negative effect on the work of the heart, the appearance of such a deviation as bradycardia, a weakening of the stroke and cardiac output.

There is a risk of increased cumulation of Warfarin and Fenindione in the blood when taken together.

Consumption in conjunction with Doscorubicin as experiments, revealed the frequent occurrence of adverse events in the cardiovascular system. Propranolol also inhibits the action of isoprenaline, salbutamol, terbutaline.

There is a possibility of an increase in the accumulation of Imipramine in the blood when taken together.

Indomethacin, Naproxen, Piroxicam, Aspirin when used in conjunction with Anaprilin, they can help to weaken the effect of propranolol on the normalization of blood pressure.

Joint reception of Anaprilin and Ketanserina contributes to the identification of additive hypotensive effects, Clonidine - a decrease in the effect of substances on the normalization of blood pressure.

If there was a mandatory cancellation of Clonidine and its replacement with Propranolol, then the probability of identifying severe arterial hypertension is possible. This phenomenon may be associated with an increase in the concentration of catecholamines in the blood and an increase in their vasoconstrictor effect.

When the drug interacts with caffeine, there is a weakening of the effect of propranolol on the body.

There is a likelihood of an intense effect of lidocaine and bupivacaine, due to a decrease in liver sensitivity when used together.

Lithium carbonate and Anaprilin contribute to the development of bradycardia.

Increased negative effect Maprotiline when taken together, due to its slow action in the liver and accumulation in the body.

Interaction Mefloquine may increase the intervals for electrocardiography, rarely - cardiac arrest.

Interaction Morphine and Anaprilin can increase the detrimental effect on the central nervous system. Anaprilin and Sodium amidotrizoate together help to lower blood pressure, the limit of which will be felt by the patient.

When taken with Nizodilpin possibly an increased accumulation of propranolol and nizoldipine in the blood, which can lead to arterial hypotension. There is also an increase in beta-blocking effects.

Taking this drug and Nikadirpina affects the increase in the cumulation of propranolol in the blood, lowering blood pressure and pulse rate.

The use of Anaprilin and Nifedipine when diagnosed with coronary heart disease, it can contribute to the maturation of such a deviation as severe arterial hypotension, the appearance heart failure and the risk of acquiring myocardial infarction, which may be a factor in the effect of Nifedipine on a change in the amplitude of cardiac reductions.

Patients with the use of Propranolol and receiving the initial dose of Prazosin have a risk of acquiring arterial hypotension.

Acceptance of Prenilamine and Anaprilin help to increase the interval of heart contractions.

When taking the drug in conjunction with Propafenone, there is an accumulation of propranolol in the blood and an increase in toxic effects. This may be due to the fact that propafenone weakens the reaction of propranolol in the liver, slowing down its excretion from the body, and also increases serum concentrations.

Joint reception with Reserpine and other drugs that help stabilize blood pressure, the likelihood of detecting such disorders, such as bradycardia or arterial hypotension, the concentration of rizatriptan in the blood may also increase; with Rifampicin - there is a weakening of the concentration of propranolol in the blood.

Suxamethonium chloride or turbocurarine chloride, when taken together, can contribute to a decrease in skeletal muscle tone.

With simultaneous use, a weakening of Theophylline excretion from the body is observed, due to its slow action in the liver.

Additionally: in patients with bronchial asthma or chronic obstructive pulmonary disease, bronchospasm may develop.

There is a fact of an increase in the tendency to bleeding without affecting blood clotting (without the development of hemophilia) when used with Flecainide.

Fluoxetine (like Quinidine) can suppress the action of the isoenzyme CYP2D6, which can lead to a deterioration in the effects of propranolol and a decrease in its excretion from the body. There may also be an increase in beta-adrenergic blocking effects and orthostatic hypotension. When taken together, there is a possibility of an increase in the concentration of propranolol and other substances in the blood. There may also be a decrease in blood pressure.

Cimetidine can suppress the activity of liver microsomal enzymes, which can lead to a weakening of the action propranolol and its accumulation, which cause an increase in negative inotropic and cardiodepressant impact.

The hypertensive effect of epinephrine is increased when taken together, which can contribute to life-threatening blood pressure disorders and bradycardia. There is a weakening of the bronchodilatory effect of epinephrine, ephedrine.

With simultaneous administration, a weakening of the action of ergotamine is observed.

The interaction of ethanol with this drug contributes to the hemodynamic action of propranolol.

Anaprilin: contraindications and side effects

Anaplilin, contraindications and side effects of which are also present, should not be used sensitive people to at least one of the components, local or absolute atrioventricular block, with weak sinus knot.

Anaprilin is contraindicated in bronchial asthma disease, Raynaud's syndrome, in diabetes mellitus with keacidosis. It is possible to use anaplilin for atic colitis. Contraindications also apply to pregnant and lactating women, the drug is prohibited for children under 1 year old.

During the period of using the drug Anaprilin, side effects appear in the digestive system.: nausea and gag reflex, pain in the epigastric region, indigestion, ischemic colitis, changes in kidney function.

In the cardiovascular and nervous systems: arterial hypotension, bradycardia, head pain, weakness, sleep disturbance or lack of sleep, anxiety and depression.

In the respiratory system: the appearance of cough, shortness of breath, broncho- and laryngospasm from the drug Anaprilin. Side effects are also manifested in the form of bald patches or hair loss, activation of psoriatic manifestations. Allergic processes can be quite rare side effects: itching on the skin or hives.

Overdose manifests itself as: clearly visible bradycardia, dizziness, AV blockade, drop in blood pressure, pre fainting, arrhythmia, extrasystole of the ventricles, HF, nail or digital cyanosis, seizures, inability to breathe easily, bronchial spasms.

Help needed: immediate gastric lavage, when changing the work of AV patency - intravenous do 1-2 mg atropine, if the expected result is not achieved due to the actions taken, then the installation of a temporary pacemaker is necessary. With extrasystole of the ventricles, lidocaine is used (class Ia drugs are not used).

The cost of the medicine is low and varies within 40 rubles.

Anaprilin, the side effects of which are manifested in humans, can be replaced with its analogue. Similar medicines include: Propranolol, Propranobene, Propaminum, Inderal, Obsidan.

Anaprilin is an antiarrhythmic, hypotensive, antianginal agent used to treat heart disease.